Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.

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Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.

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Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.

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Interferon gamma inhibits interleukin 10 production by monocytes

Interleukin 10 (IL-10) was first described for its ability to inhibit interferon gamma (IFN-gamma) production. Herein, we studied the balance between IFN-gamma and IL-10 production by human peripheral blood mononuclear cells (PBMC) in response to Staphylococcus aureus Cowan (SAC) or lipopolysaccharide (LPS). Monocyte depletion reduced IL-10 production by 90% and resulted in an increased IFN-gam...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1997

ISSN: 0021-9738

DOI: 10.1172/jci119162